Product ID:BUPIVACAINE HYDROCHLORIDE INJ., USP, 5756
MSDS Date:12/13/1991
FSC:6505
NIIN:01-127-7946
MSDS Number: BWLGD

Emergency Phone: 708-937-6100

Info Phone: 312-937-7901/708-937-6100

Cage: 60060

Telephone: 847-935-7177

Cage: 60060

AQUEOUS SOLUTION

BUPIVACAINE HYDROCHLORIDE

CAS: 18910-40-7

LD50 LC50 Mixture:LD50 ORAL,RABBITS =18MG/KG.
Routes of Entry: Inhalation:NO Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:LOCAL ANESTHETIC THAT PRODUCES
ANESTHESIA (NUMBNESS) BY BLOCKAGE OF NERVE CONDUCTION & CAN ALSO
ADVERSELY AFFECT CNS & HEART. HAS POTENTIAL TO PRODUCE FETAL
TOXICITY IN HUMANS.
Explanation of Carcinogenicity:PER
MSDS:CARCINOGENICITY:NTP/IARC/OSHA:NOT LISTED.
Effects of Overexposure:NONE FROM INTACT VIALS. IN CLINICAL USE EFFECTS
INCLUDE NUMBNESS, EXCITATION/DEPRESSION, RESTLESSNESS, ANXIETY,
DIZZINESS, TINNITUS, BLURRED VISION, TREMORS, CONVULSIONS,
HYPOTENSION, BRADYCARDIA, VEN TRICULAR ARRHYTHMIAS, HEART BLOCK,
AND CARDIAC ARREST.
Medical Cond Aggravated by Exposure:NONE FROM INTACT VIAOLS. DATA
SUGGEST PRE-EXISTING CENTRAL NERVOUS SYSTEM OR CARDIOVASCULAR
AILMENTS. HYPERSENSITIVITY TO AMIDE-TYPE LOCAL ANESTHETICS.

First Aid:REMOVE FOR SOURCES OF EXPOSURE. IF SKIN OR EYE CONTACT, FLUSH
WITH COPIOUS AMOUNTS OF WATER. IF IRRITATION PERSISTS OR SIGNS OF
TOXICITY OCCUR SEEK MEDICAL ATTENTION. NO KNOWN ANTIDOTE. PROVIDE
SYMPTO MATIC/SUPPORTIVE CARE, MAINTAINING VENTILATION, CONTROLLING
CONVULSIONS, & MONITORING CARDIOVASCULAR FUNCITON AS NECESSARY.

Flash Point:NON-FLAMMABLE
Extinguishing Media:PER MSDS N/A. HOWEVER USE MEDIA APPROPRIATE FOR
PRIMARY CAUSE OF FIRE.
Fire Fighting Procedures:NONE.
Unusual Fire/Explosion Hazard:NONE.

Spill Release Procedures:CLEAN UP PROMPTLY, AVOID SKIN/EYE CONTACT.

Handling and Storage Precautions:NONE.
Other Precautions:NONE.

Ventilation:NO SPECIAL PROVISIONS REQUIRED.
Protective Gloves:NONE REQUIRED.
Eye Protection:NONE REQUIRED.
Work Hygienic Practices:USE GOOD CLINICAL AND HYGIENIC PRACTICES.
Supplemental Safety and Health

HCC:N1
Boiling Pt:B.P. Text:WATER(APPR)
Melt/Freeze Pt:M.P/F.P Text:WATER(APPR)
Spec Gravity:WATER(APPROX)
pH:4-6.5
Solubility in Water:AQUEOUS SOLUTION
Appearance and Odor:CLEAR LIQUID.
Percent Volatiles by Volume:NEGLIG

Stability Indicator/Materials to Avoid:YES
NONE.
Stability Condition to Avoid:NONE.
Hazardous Decomposition Products:NONE.

Waste Disposal Methods:NO SPECIAL REQUIREMENTS.

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.